Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity

<p>Abstract</p> <p>Context</p> <p>Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed.</p> <p>Objective</p> <p>To investigate the possibility of the existence of a crosstalk between the <it>CALPAIN 10 </it>homologue <it>CALPAIN 5 </it>and nuclear receptors of the peroxisome proliferator-activated receptors family.</p> <p>Design</p> <p>Cross-sectional, genetic association study and gene-gene interaction analysis.</p> <p>Subjects</p> <p>The study sample comprise 1953 individuals, 725 obese (defined as body mass index ≥ 30) and 1228 non obese subjects.</p> <p>Results</p> <p>In the monogenic analysis, only the peroxisome proliferator-activated receptor delta (<it>PPARD</it>) gene was associated with obesity (OR = 1.43 [1.04–1.97], p = 0.027). In addition, we have found a significant interaction between <it>CAPN5 </it>and <it>PPARD </it>genes (p = 0.038) that reduces the risk for obesity in a 55%.</p> <p>Conclusion</p> <p>Our results suggest that <it>CAPN5 </it>and <it>PPARD </it>gene products may also interact in vivo.</p

Present Status and Future Perspectives of the NEXT Experiment

NEXT is an experiment dedicated to neutrinoless double beta decay searches in xenon. The detector is a TPC, holding 100 kg of high-pressure xenon enriched in the 136Xe isotope. It is under construction in the Laboratorio Subterráneo de Canfranc in Spain, and it will begin operations in 2015. The NEXT detector concept provides an energy resolutionbetter than 1% FWHM and a topological signal that can be used to reduce the background. Furthermore, the NEXT technology can be extrapolated to a 1 ton-scale experiment

D4.3 Final Report on Network-Level Solutions

Research activities in METIS reported in this document focus on proposing solutions to the network-level challenges of future wireless communication networks. Thereby, a large variety of scenarios is considered and a set of technical concepts is proposed to serve the needs envisioned for the 2020 and beyond. This document provides the final findings on several network-level aspects and groups of solutions that are considered essential for designing future 5G solutions. Specifically, it elaborates on: -Interference management and resource allocation schemes -Mobility management and robustness enhancements -Context aware approaches -D2D and V2X mechanisms -Technology components focused on clustering -Dynamic reconfiguration enablers These novel network-level technology concepts are evaluated against requirements defined by METIS for future 5G systems. Moreover, functional enablers which can support the solutions mentioned aboveare proposed. We find that the network level solutions and technology components developed during the course of METIS complement the lower layer technology components and thereby effectively contribute to meeting 5G requirements and targets.Aydin, O.; Valentin, S.; Ren, Z.; Botsov, M.; Lakshmana, TR.; Sui, Y.; Sun, W.... (2015). D4.3 Final Report on Network-Level Solutions. http://hdl.handle.net/10251/7675

EU FP7 INFSO-ICT-317669 METIS, D4.2 Final report on trade-off investigations

Research activities in METIS WP4 include several aspects related to the network-level of future wireless communication networks. Thereby, a large variety of scenarios is considered and solutions are proposed to serve the needs envisioned for the year 2020 and beyond. This document provides vital findings about several trade-offs that need to be leveraged when designing future network-level solutions. In more detail, it elaborates on the following trade-offs:• Complexity vs. Performance improvement• Centralized vs. Decentralized• Long time-scale vs. Short time-scale• Information Interflow vs. Throughput/Mobility enhancement• Energy Efficiency vs. Network Coverage and CapacityOutlining the advantages and disadvantages in each trade-off, this document serves as a guideline for the application of different network-level solutions in different situations and therefore greatly assists in the design of future communication network architectures

EU FP7 INFSO-ICT-317669 METIS, D4.2 Final report on trade-off investigations

Research activities in METIS WP4 include several aspects related to the network-level of future wireless communication networks. Thereby, a large variety of scenarios is considered and solutions are proposed to serve the needs envisioned for the year 2020 and beyond. This document provides vital findings about several trade-offs that need to be leveraged when designing future network-level solutions. In more detail, it elaborates on the following trade-offs: • Complexity vs. Performance improvement • Centralized vs. Decentralized • Long time-scale vs. Short time-scale • Information Interflow vs. Throughput/Mobility enhancement • Energy Efficiency vs. Network Coverage and Capacity Outlining the advantages and disadvantages in each trade-off, this document serves as a guideline for the application of different network-level solutions in different situations and therefore greatly assists in the design of future communication network architectures

Near-intrinsic energy resolution for 30-662 keV gamma rays in a high pressure xenon electroluminescent TPC

We present the design, data and results from the NEXT prototype for Double Beta and Dark Matter (NEXT-DBDM) detector, a high-pressure gaseous natural xenon electroluminescent time projection chamber (TPC) that was built at the Lawrence Berkeley National Laboratory. It is a prototype of the planned NEXT-100 136Xe neutrino-less double beta decay (0νββ) experiment with the main objectives of demonstrating near-intrinsic energy resolution at energies up to 662 keV and of optimizing the NEXT-100 detector design and operating parameters. Energy resolutions of ∼1% FWHM for 662 keV gamma rays were obtained at 10 and 15 atm and ∼5% FWHM for 30 keV fluorescence xenon X-rays. These results demonstrate that 0.5% FWHM resolutions for the 2459 keV hypothetical neutrino-less double beta decay peak are realizable. This energy resolution is a factor 7-20 better than that of the current leading 0νββ experiments using liquid xenon and thus represents a significant advancement. We present also first results from a track imaging system consisting of 64 silicon photo-multipliers recently installed in NEXT-DBDM that, along with the excellent energy resolution, demonstrates the key functionalities required for the NEXT-100 0νββ searc